Three unconnected Brooklyn cops wind up at the same deadly location after enduring vastly different career paths. The story revolves around three New York police officers over one week. Eddie is a patrolman played by Richard Gere who only has 7 days left before he can pull the pin and retire. Undercover cop Tango played by Don Cheadle has been on the streets too long, causing him to protect Caz (Wesley Snipes) the drug kingpin target he is out to catch. Sal (Ethan Hawke) is a narcotics cop who is under tremendous pressure to provide a healthy home for his pregnant wife and two children.
It's 1954, and up-and-coming U.S. marshal Teddy Daniels is assigned to investigate the disappearance of a patient from Boston's Shutter Island Ashecliffe Hospital. He's been pushing for an assignment on the island for personal reasons, but before long he wonders whether he hasn't been brought there as part of a twisted plot by hospital doctors whose radical treatments range from unethical to illegal to downright sinister. Teddy's shrewd investigating skills soon provide a promising lead, but the hospital refuses him access to records he suspects would break the case wide open. As a hurricane cuts off communication with the mainland, more dangerous criminals "escape" in the confusion, and the puzzling, improbable clues multiply, Teddy begins to doubt everything - his memory, his partner, even his own sanity.
As homicide detective Thomas Craven investigates the death of his activist daughter, he uncovers not only her secret life, but a corporate cover-up & government collusion that attracts an agent tasked with cleaning up the evidence.